Contents
SECTION I: BASIC PRINCIPLES Chapter 1: Introduction: The Nature of Drugs & Drug Development & Regulation Chapter 2: Drug Receptors & Pharmacodynamics Chapter 3: Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action Chapter 4: Drug Biotransformation Chapter 5: Pharmacogenomics SECTION II: AUTONOMIC DRUGS Chapter 6: Introduction to Autonomic Pharmacology Chapter 7: Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs Chapter 8: Cholinoceptor-Blocking Drugs Chapter 9: Adrenoceptor Agonists & Sympathomimetic Drugs Chapter 10: Adrenoceptor Antagonist Drugs SECTION III: CARDIOVASCULAR-RENAL DRUGS Chapter 11: Antihypertensive Agents Chapter 12: Vasodilators & the Treatment of Angina Pectoris Chapter 13: Drugs Used in Heart Failure Chapter 14: Agents Used in Cardiac Arrhythmias Chapter 15: Diuretic Agents SECTION IV: DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE Chapter 16: Histamine, Serotonin, & the Ergot Alkaloids Chapter 17: Vasoactive Peptides Chapter 18: The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds Chapter 19: Nitric Oxide Chapter 20: Drugs Used in Asthma SECTION V: DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM Chapter 21: Introduction to the Pharmacology of CNS Drugs Chapter 22: Sedative-Hypnotic Drugs Chapter 23: The Alcohols Chapter 24: Antiseizure Drugs Chapter 25: General Anesthetics Chapter 26: Local Anesthetics Chapter 27: Skeletal Muscle Relaxants Chapter 28: Pharmacologic Management of Parkinsonism & Other Movement Disorders Chapter 29: Antipsychotic Agents & Lithium Chapter 30: Antidepressant Agents Chapter 31: Opioid Agonists & Antagonists Chapter 32: Drugs of Abuse SECTION VI: DRUGS USED TO TREAT DISEASES OF THE BLOOD, INFLAMMATION, & GOUT Chapter 33: Agents Used in Cytopenias; Hematopoietic Growth Factors Chapter 34: Drugs Used in Disorders of Coagulation Chapter 35: Agents Used in Dyslipidemia Chapter 36: Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout SECTION VII: ENDOCRINE DRUGS Chapter 37: Hypothalamic & Pituitary Hormones Chapter 38: Thyroid & Antithyroid Drugs Chapter 39: Adrenocorticosteroids & Adrenocortical Antagonists Chapter 40: The Gonadal Hormones & Inhibitors Chapter 41: Pancreatic Hormones & Antidiabetic Drugs Chapter 42: Agents That Affect Bone Mineral Homeostasis SECTION VIII: CHEMOTHERAPEUTIC DRUGS Section VIII: Chemotherapeutic Drugs: Introduction Chapter 43: Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics Chapter 44: Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones Chapter 45: Aminoglycosides & Spectinomycin Chapter 46: Sulfonamides, Trimethoprim, & Quinolones Chapter 47: Antimycobacterial Drugs Chapter 48: Antifungal Agents Chapter 49: Antiviral Agents Chapter 50: Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, & Sterilants Chapter 51: Clinical Use of Antimicrobial Agents Chapter 52: Antiprotozoal Drugs Chapter 53: Clinical Pharmacology of the Antihelminthic Drugs Chapter 54: Cancer Chemotherapy Chapter 55: Immunopharmacology SECTION IX: TOXICOLOGY Chapter 56: Introduction to Toxicology: Occupational & Environmental Chapter 57: Heavy Metal Intoxication & Chelators Chapter 58: Management of the Poisoned Patient SECTION X: SPECIAL TOPICS Chapter 59: Special Aspects of Perinatal & Pediatric Pharmacology Chapter 60: Special Aspects of Geriatric Pharmacology Chapter 61: Dermatologic Pharmacology Chapter 62: Drugs Used in the Treatment of Gastrointestinal Diseases Chapter 63: Therapeutic & Toxic Potential of Over-the-Counter Agents Chapter 64: Dietary Supplements & Herbal Medications Chapter 65: Rational Prescribing & Prescription Writing Chapter 66: Important Drug Interactions & Their Mechanisms Appendix: Vaccines, Immune Globulins, & Other Complex Biologic Products

Abstract
"The fourteenth edition of Basic & Clinical Pharmacology continues the extensive use of full-color illustrations and expanded coverage of transporters, pharmacogenomics, and new drugs of all types emphasized in prior editions. In addition, it reflects the major expansion of large-molecule drugs in the pharmacopeia, with numerous new monoclonal antibodies and other biologic agents. Case studies accompany most chapters, and answers to questions posed in the case studies appear at the end of each chapter. The book is designed to provide a comprehensive, authoritative, and readable pharmacology textbook for students in the health sciences. Frequent revision is necessary to keep pace with the rapid changes in pharmacology and therapeutics; the 2-3 year revision cycle of this text is among the shortest in the field, and the availability of an online version provides even greater currency. The book also offers special features that make it a useful reference for house officers and practicing clinicians."